Vitamin B12 deficiency: Cognitive impairment and neuroimaging correlates
نویسندگان
چکیده
Vitamin B12 deficiency has been associated with various neuropsychiatric symptoms, and to be a reversible cause of dementia. As the negative impact of low vitamin B12 status on cognition can range from subclinical neuronal metabolic derangement to an overt debilitating state in line with permanent brain structural changes, prompt recognition of vitamin B12 deficiency is of paramount clinical importance as it is a treatable condition. Several studies have investigated the pathogenesis of vitamin B12 deficiency.
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Vitamin B12 deficiency is common in older people and is associated with cognitive impairment in the absence of anaemia or macrocytosis [1–3]. The prevalence of vitamin B12 deficiency increases in the elderly, mainly due to malabsorption of food-bound vitamin B12 due to atrophic gastritis that limits the ability of older people to release vitamin B12 from dietary sources in meat, fish and dairy ...
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